Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility

Article ID	Journal	Published Year	Pages	File Type
3200583	Journal of Allergy and Clinical Immunology	2009	9 Pages	PDF

Abstract

The association between TLR4 variants and reduced airway responsiveness to inhaled particulate was observed at high endotoxin concentrations, creating the possibility of certain threshold phenomena for the apparent protective effect of TLR4 variants.

Keywords

FEV1 FVC TLR4 FEF25-75 Forced expiratory flow between 25% and 75% of forced vital capacity PC20 Endotoxin gene-environment interaction Forced Expiratory Volume in the first second Cytokines Blood counts forced vital capacity Lung function Airway hyperresponsiveness Toll-like receptor 4

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility

Authors

Ambikaipakan PhD, James A. MD, Liliane MSc, Lauranell H. PhD, Bernardo Z. PhD, Randine BSN, David MSc, Tom MVetSc, Shelley PhD, Volker PhD, Yvon MD, Donna C. PhD, David A. MD,