| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3200720 | Journal of Allergy and Clinical Immunology | 2008 | 6 Pages |
Abstract
In addition to increased serum TGF-β1 levels, the T allele of the C-509T polymorphism is related to increased airflow obstruction but attenuated eosinophilic inflammation. The former relation is not attributed to thickening of the central airway walls. The latter relation might reflect the anti-inflammatory effect of TGF-β1. The C-509T polymorphism has a complex role in asthma pathophysiology, presumably because of the diverse functions of TGF-β1 and its various interactions with cells and humoral factors in vivo.
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Authors
Tetsuya MD, PhD, Akio MD, PhD, Hisako MD, PhD, Masaya MD, PhD, Masafumi MD, Hirofumi MD, Makiko MD, Kazuo MD, PhD, Masayoshi MD, PhD, Lei MD, PhD, Taro MD, PhD, Michiaki MD, PhD,