| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3200826 | Journal of Allergy and Clinical Immunology | 2010 | 17 Pages |
Abstract
These results point to a physiologic negative regulatory role for the Y709 ITIM in signaling through IL-4Rα, especially by IL-13.
Keywords
AHRPhosphatidylinositol 3IL-4 receptor α chainIL-4RαEpoRIL-4RIL-13PI3BMDMITIMIRSIgEIL-4OVAERKJanus kinaseAsthmaAlumSTATperiodic acid–SchiffAllergic airway inflammationinsulin receptor substrateOvalbuminBone marrow–derived macrophageSignal transducer and activator of transcriptionImmunoreceptor tyrosine-based inhibitory motifmapPASwild-typeAirway hyperresponsivenessmitogen-activated proteinJAKSHIP-1extracellular signal-regulated kinaseIL-4 receptorErythropoietin Receptor
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Authors
Raffi MD, Shadi MD, Andreas MD, Hong Sook PhD, Andrew Chen, Julie PhD, Clinton PhD, Hye Young PhD, Dale T. MD, PhD, Hans C. MD, PhD, Talal A. MD, MSc,