| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3200940 | Journal of Allergy and Clinical Immunology | 2009 | 11 Pages |
Abstract
sPLA2 activity is increased in the airways of asthmatic patients. HLMCs express multiple sPLA2s and release 1 or more of them when activated by anti-IgE. The sPLA2s released by mast cells contribute to LTC4 production by acting in an autocrine fashion. Mast cells can be a source of sPLA2s in the airways of asthmatic patients.
Keywords
qPCRDTTHuman lung mast cellIC50GAPDHHLMCLTC4PMSFBMMCcPLA2sPLA2PLA2cycle thresholdArachidonic acidOleic acidBALFdithiothreitolreal-time quantitative PCRBone marrow–derived mast cellInhibitory concentration of 50%Secreted phospholipase A2cytosolic phospholipase A2phenylmethylsulfonyl fluorideLeukotriene C4Bronchoalveolar lavage fluidglyceraldehyde-3-phosphate dehydrogenase
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Authors
Massimo MD, PhD, Giorgio MD, Cecilia MD, PhD, Stefania PhD, Francescopaolo MD, PhD, Alfonso MD, Mario MD, Michael H. PhD, Gianni MD, FRCP,