| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3201117 | Journal of Allergy and Clinical Immunology | 2009 | 12 Pages |
Abstract
IL-17-capable T cells, in particular TH2/IL-17 cells, infiltrate acute AE reactions. Although IL-17 secretion by specific T cells is tightly regulated, it can be triggered by bacteria-derived superantigens. The ineffective IL-17-dependent upregulation of HBD-2 in patients with AE is due to a partial inhibition by the type 2 microenvironment, which could partially explain why patients with AE do not clear S aureus.
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Authors
Kilian MD, Davide PhD, Claudia PhD, Stefanie PhD,, Francesca PhD, Heidrun MD, Johannes MD, PhD, Claudia MD, Cristina PhD, Andrea MD, PhD,