Article ID Journal Published Year Pages File Type
3201195 Journal of Allergy and Clinical Immunology 2008 10 Pages PDF
Abstract
Sftpd−/− mice have an impaired systemic TH2 response at baseline and reduced inflammation and airway responses after allergen exposure. Translational studies revealed that a polymorphism in the SFTPD gene was associated with lower atopy and possibly asthma susceptibility. Taken together, these results support the hypothesis that SP-D-dependent innate immunity influences atopy and asthma.
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Authors
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