| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3202444 | Journal of Allergy and Clinical Immunology | 2008 | 13 Pages |
Abstract
The SPINK5 420LysSer mutation confers a risk of eczema when maternally inherited but is not a major eczema risk factor. The KLK7 insertion appears to confer no risk of eczema. We found no interaction between the SPINK5 risk allele or the putative KLK7 risk allele and FLG mutations.
Keywords
ALSPACstratum corneum chymotryptic enzymeLEKTISPINK5KLK7FLGAICAtopyAvon Longitudinal Study of Parents and ChildrenEpistasisEczemaStratum corneumskin barrierAkaike information criterionUTR یا untranslated regions untranslated regionodds ratioUnited KingdomSingle nucleotide polymorphismSNPfilaggrin geneKORA
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Authors
Stephan MD, PhD, Hansjörg MSc, Stefan PhD, John MD, Natalija MD, Aileen PhD, Huijia BSc, Elke PhD, Grainne M. MRCPI, Rosemarie MD, Haihui MD, Yiwei MD, Jonathan N.W.N. MD, Michael PhD, Nick MD, Simon MD, Kate PhD, George D. DSc, Alan D. MD,