12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels

Article ID	Journal	Published Year	Pages	File Type
3202455	Journal of Allergy and Clinical Immunology	2008	10 Pages	PDF

Abstract

Induction of 15-LO-1 in asthma might contribute to allergic sensitization and airways inflammation, potentially by causing suppression of secretory IgA.

Keywords

Cysteinyl leukotriene TACI BAFF receptor IL-13 Stat6 BCMA BAFF-R CysLT B-cell maturation antigen J chain HODE pIgR sIgA Asthma Allergy APRIL Arachidonic acid hydroxyeicosatetraenoic acid hydroxyoctadecadienoic acid inflammation IgA BAFF BALF secretory component Secretory IgA Airway Lung B cells transmembrane activator and calcium modulator and cyclophilin ligand interactor Leukotriene lipoxygenase Bronchoalveolar lavage fluid Signal transducer and activator of transcription 6 HETE prostaglandin polymeric immunoglobulin receptor a proliferation-inducing ligand

Related Topics

Life Sciences Immunology and Microbiology Immunology

12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels

Authors

Amanda R. BS, Alexa R. BS, Silvio PhD, Roderick BS, Robert P. PhD, Douglas A. PhD,