| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3202843 | Journal of Allergy and Clinical Immunology | 2008 | 15 Pages |
Abstract
Anti-IL-5 therapy induces a dramatic and sustained decrease in blood eosinophilia (including CCR3+ cells), decreased eosinophil activation, and increased circulating levels of IL-5 in a variety of eosinophilic disorders. Increased levels of IL-5 receptor α and lymphocyte IL-5 production after anti-IL-5 therapy suggest an endogenous IL-5 autoregulatory pathway.
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Authors
Miguel L. MD, Joyce M. BS, Bridget K. BA, Yoshiyuki MD, Alexandra H. MD, Amal H. MD, Marc E. MD, PhD,