Palmoplantar pustules and osteoarticular pain in a 42-year-old woman

Key teaching points• Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a spectrum of neutrophilic dermatoses.• The most common dermatologic manifestations include palmoplantar pustulosis, acne conglobata, and acne fulminans.• SAPHO syndrome should be considered in patients presenting osteoarticular pain, particularly involving the anterior chest wall and/or spine, and neutrophilic skin lesions.