Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3205903 | Journal of the American Academy of Dermatology | 2012 | 12 Pages |
Abstract
Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have called into question whether the current recommended intake of vitamin D is too low for optimal health and cancer prevention. Part I will review the role of vitamin D in the epidermis; part II will review the role of vitamin D in keratinocyte-derived tumors to help frame the discussion on the possible role of vitamin D in the prevention of skin cancer.
Keywords
25(OH)D levelsSPFRDAUVBNMSCCholecalciferolVDRIOMVDBP1,25(OH)2D25(OH)D25-hydroxyvitamin DUltravioletUltraviolet radiationultraviolet BRecommended dietary allowancenonmelanoma skin cancerbody mass indexBMISun protection factorInstitute of MedicineSupplementsinternational unitVitamin DVitamin D binding proteinVitamin D receptor
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Jean Y. MD, PhD, Teresa MD, Christopher BA, Dennis H. MD, PhD, Daniel D. MD, PhD, Maryam M. MD, MPH,