Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3207323 | Journal of the American Academy of Dermatology | 2011 | 18 Pages |
Abstract
Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Edgar S. Macias, Frederick A. Pereira, William Rietkerk, Bijan Safai,