Angioplasmocellular hyperplasia: A clinicopathologic study of 10 patients

BackgroundAngioplasmocellular hyperplasia is rarely reported.ObjectiveThe purpose of this study is to describe and analyze the clinicopathologic features of angioplasmocellular hyperplasia.MethodsThe records of 10 patients (mean age, 45 years; range, 17 to 71 years) with characteristic histologic features of angioplasmocellular hyperplasia were reviewed and the histopathologic findings, clinical features, and medical histories analyzed. Formalin-fixed, paraffin-embedded specimens were examined by immunohistochemical staining.ResultsThe most common clinical appearance was a single nodule with an erythematous rim. Histologically, the inflammatory infiltrate comprised mainly polyclonal plasma cells. There was vascular proliferation of capillaries and venules with varying numbers of plump endothelial cells. There were no definite predisposing factors.LimitationsThe number of cases was limited and all patients were Asian.ConclusionsAngioplasmocellular hyperplasia had a distinct clinical appearance characterized by its inflammatory rim. The nature of the infiltrating cells and distribution of blood vessels indicates that it is a form of reactive plasmocytic inflammatory vascular hyperplasia.