Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
320907 | European Neuropsychopharmacology | 2008 | 4 Pages |
Abstract
We here show that repeated administration of the first generation antipsychotic haloperidol, but not of the second generation olanzapine, significantly reduced the expression of NMDA subunit NR2A at striatal synapses, whereas both drugs decreased αCaMKII protein levels and autophosphorylation degree. Given that alterations in the localization of NMDA receptor regulatory subunits at synapses have been described in experimental parkinsonism, the haloperidol-induced effect on NMDA subunit localization might contribute to drug-induced parkinsonism induced by haloperidol.
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Authors
Fabrizio Gardoni, Angelisa Frasca, Elisa Zianni, Marco A. Riva, Monica Di Luca, Fabio Fumagalli,