Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3209528 | Journal of the American Academy of Dermatology | 2007 | 5 Pages |
Abstract
A 91-year-old woman who had been taking methotrexate for approximately 5 years for rheumatoid arthritis developed papules and nodules on her face that enlarged during 6 months. A series of biopsy specimens demonstrated a lymphoplasmacytic infiltrate with increasingly atypical histopathologic features that resembled diffuse large B-cell lymphoma. Epstein-Barr virus was not identified. Withdrawal of methotrexate resulted in complete resolution of all lesions within 8 weeks. This case illustrates the rare occurrence of methotrexate-associated lymphoproliferative disorder with primary presentation in the skin and documents clinical and histopathologic progression from early changes to fully developed lesions.
Keywords
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Dermatology
Authors
Loren E. Clarke, Jacqueline Junkins-Hopkins, John T. Seykora, Donald J. Adler, Rosalie Elenitsas,