Clinical experience in pemphigoid gestationis: Report of 10 cases

BackgroundPemphigoid gestationis is a rare autoimmune blistering disease that occurs during pregnancy.ObjectiveThis study reviewed our clinical experience with pemphigoid gestationis.MethodsWe reviewed medical records of 10 patients with pemphigoid gestationis seen at Mayo Clinic, Rochester, Minnesota, between 1976 and 2004.ResultsUrticarial papules were the most frequent clinical presentation followed by blisters and rash. Pruritus was the cardinal symptom. Lesions presented initially on the legs, thighs, back, and chest. Direct immunofluorescence had the highest diagnostic test sensitivity. Systemic corticosteroids were the mainstay of treatment. Fetal and maternal outcome was good in all cases.LimitationsThis was a retrospective, single-institution study.ConclusionsThis condition can be easily confused with other dermatoses of pregnancy, for example, pruritic urticarial papules of pregnancy. Biopsy for direct immunofluorescence is the preferred test for confirmation of diagnosis. On the basis of good patient outcomes, conservative treatment seems warranted.