Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3214582 | Journal of Dermatological Science | 2006 | 10 Pages |
Abstract
SummaryDeimination corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Catalyzed by peptidylarginine deiminases, it decreases the net positive charge of proteins, alters intra and intermolecular ionic interactions and probably the folding of target proteins. Deimination has recently been implicated in several physiological and pathological processes. Here, we describe the enzymes involved in this post-translational modification, focusing on their expression, location and roles in skin, as well as their known protein substrates in the epidermis and hair follicles. We discuss also the potential involvement of deimination in human diseases including cutaneous disorders.
Keywords
Related Topics
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Medicine and Dentistry
Dermatology
Authors
Stéphane Chavanas, Marie-Claire Méchin, Rachida Nachat, Véronique Adoue, Fanny Coudane, Guy Serre, Michel Simon,