| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3214869 | Journal of Investigative Dermatology | 2016 | 8 Pages |
Abstract
The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than those for other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cutaneous squamous cell carcinoma. WNT pathways are aberrantly regulated in multiple tumor types (albeit in a context-dependent manner), and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cutaneous squamous cell carcinoma and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Victoria Sherwood, Irene M. Leigh,