| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3215980 | Journal of Investigative Dermatology | 2010 | 4 Pages |
Abstract
The roles of connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-β, and type I procollagen expression and content. CTGF knockdown and TGF-β blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-β/Smad signaling–dependent mechanism without involving Smad2/3.
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Authors
Noelynn Oliver, Mark Sternlicht, Karin Gerritsen, Roel Goldschmeding,