| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3216457 | Journal of Investigative Dermatology | 2009 | 12 Pages |
Abstract
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.
Related Topics
Health Sciences
Medicine and Dentistry
Dermatology
Authors
Antonella Di Cesare, Paola Di Meglio, Frank O. Nestle,