| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 321720 | European Neuropsychopharmacology | 2006 | 5 Pages |
Abstract
Several trials have indicated that selective serotonin reuptake inhibitors (SSRIs) are most efficient in the treatment of social phobia (SP). The activity of the serotonin transporter (5-HTT), as determined by [3H]5-HT uptake to blood lymphocytes, was measured in 15 drug-free patients with generalized SP (7M/8F, aged 21–37 years) and compared to 18 healthy control subjects (10M/8F, aged 21–32 years). The maximum uptake velocity (Vmax) of [3H]5-HT to fresh lymphocytes and the affinity (Km) of the 5-HTT were similar in the two groups (295 ± 155 versus 227 ± 117 pmol/min/mg protein and 767 ± 425 versus 709 ± 408 nM, respectively). This study suggests that the functioning of lymphocyte 5-HTT is unaltered in SP.
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Authors
Tal Barkan, Haggai Hermesh, Sofi Marom, David Gurwitz, Abraham Weizman, Moshe Rehavi,