Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
321927 | European Neuropsychopharmacology | 2010 | 4 Pages |
Abstract
NR2B-subtype-selective antagonists differ from MK-801, a nonselective NMDA receptor antagonist. MK-801 antagonizes electrical seizures at doses as low as 0.1 to 0.18 mg/kg and elicits popping at doses as low as 0.5 mg/kg, whereas ifenprodil and Ro 8-4304 were unable to do so at the doses tested. Ro 25-6981, however, was able to antagonize electrically-precipitated tonic hindlimb extension at 100 mg/kg, but was not able to elicit popping behavior at this dose.
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Authors
Jessica A. Burket, John Mastropaolo, Richard B. Rosse, Elionora U. Katz, Stephen I. Deutsch,