Correlation of Her-2 neu over-expression with clinico pathological features of carcinoma breast

PurposeTo determine the relationship between Her-2 neu over-expression and clinico pathological features of carcinoma breast.Methods150 patients with carcinoma breast, were assessed for Her-2 neu over-expression as a prospective study. Oestrogen (ER) and progesterone receptor (PR) status along with other clinico pathological parameters of tumour size, node status, type and grade of tumour were assessed.ResultsHer-2 neu over-expression was seen in 32.30% of patients who were ER and PR negative and in 11.94% of those who were ER and PR positive. It was unrelated to the other clinico pathological parameters.ConclusionsSignificant correlation between Her-2 neu amplification and ER/PR negative tumours was found but not with other clinico pathological parameters.