Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3238686 | Injury | 2016 | 4 Pages |
IntroductionThe present study investigated the effects of induced hypertension on hippocampal cell death after forebrain ischaemia in rats.Materials and methodsIn this study, forebrain ischaemia was induced in 20 Sprague-Dawley rats by clamping the bilateral common carotid arteries to induce systemic hypotension for 8 min. All rats then underwent reperfusion during which the induced hypertension group (n = 10) received intermittent intravenous injections of phenylephrine (5 μg) to maintain their mean arterial blood pressure at 20 mmHg above baseline for 10 min and the control group (n = 10) did not receive any treatment. In both groups, the numbers of viable and apoptotic neuronal cells in the cornu ammonis 1 (CA1) area of the hippocampus were evaluated 7 days after the induction of ischaemia.ResultsThe mean percentage of viable neuronal cells was higher in the induced hypertension group than in the control group (35% vs. 26%, respectively; p = 0.004), but there was no significant difference in the proportion of apoptotic neuronal cells between the groups (57% vs. 43%, respectively; p = 0.165).ConclusionsInduced hypertension significantly attenuated necrotic cell death in the hippocampal CA1 area, but apoptotic cell death was not affected.