Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3251706 | Journal of Orthopaedics | 2015 | 5 Pages |
Abstract
IntroductionMyopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells.Methods/ResultsWe present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma.ConclusionsSome of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.
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Authors
Aaron W. James, Le Chang, Swati Shrestha, Carlos A. Tirado, Sarah M. Dry,