A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery after surgery (ERAS) total knee replacement

BackgroundThe aim of this study was to compare the topical to IV tranexamic acid (TXA) administration of the same dose, given at the same time in patients who underwent TKR using an enhanced recovery after surgery (ERAS) regime.MethodsNinety patients were randomized in control group, and IV and topical application groups received 1 g TXA.ResultsBlood loss and transfusion requirements in control group were statistically higher compared to both TXA groups (p < 0.05). Length of stay was the same in all groups.ConclusionsTXA reduced significantly the blood loss and the need for transfusion in ERAS primary unilateral TKR.