Radiological and histopathological examination of apparent lytic lesions in allograft long bones—No cause for concern

ObjectiveIdentify the nature of apparent lytic lesions within human allograft specimens from patients with no known malignancy, using radiological and histopathological analysisMethods123 Post-retrieval radiographs from 23 donors were examined. Sixty-seven radiographs were noted to show apparent lytic lesions. The number, size, character and position of the apparent lesions were recorded.ResultsCT scanning of 9 specimens confirmed the lesions to be of air pockets causing artefact. Histopathological analysis showed no malignant or pathological process.ConclusionsApparent lesions were not pathological.Practice implicationsSpecimens with similar appearances, in donors with no malignancy, can be safely used in donation.