Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3251799 | Journal of Orthopaedics | 2015 | 4 Pages |
Abstract
Vascular leiomyoma are uncommon, clinically benign smooth muscle tumors. Here we report a case of an otherwise typical leiomyoma with unusual cytogenetic changes including t(1;10). Reports from the existing literature suggest that approximately 40–50% of leiomyomas contain nonrandom chromosomal abnormalities of which a subset is tumor specific. t(12;14)(q15;q24) is one of the most common translocations, which occur in approximately 20% of karyotypes. Additional aberrations include del(7)(q22-q32), trisomy 12, and 6p21 rearrangements. Other recurrent abnormalities include monosomy 22, monosomy 10, del(10q), and structural rearrangements of chromosome 3.
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Authors
Le Chang, Nagesh Rao, Nicholas Bernthal, Sarah M. Dry, Aaron W. James,