Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3254073 | Best Practice & Research Clinical Gastroenterology | 2014 | 11 Pages |
Abstract
Gastric cancer (GC) is the third leading cause of cancer-related death worldwide and it mostly develops in long-standing inflammatory conditions, and Helicobacter pylori-gastritis, in particular. Despite the increasing understanding of both the phenotypic alterations and the molecular mechanisms occurring during GC multi-step carcinogenesis, no reliable biomarker is available to be reliably implemented into GC secondary prevention strategies. Multidisciplinary diagnostic approaches integrating endoscopy, serology, histology and molecular profiling currently appears as the most appropriate approach for patients' stratification into different GC risk classes.
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Authors
Massimo Rugge, Lisette G. Capelle, Matteo Fassan,