Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3254340 | Best Practice & Research Clinical Gastroenterology | 2013 | 19 Pages |
Abstract
Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.
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Authors
Massimo Rugge, Lisette G. Capelle, Rocco Cappellesso, Donato Nitti, Ernst J. Kuipers,