| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3256990 | Clinical Immunology | 2012 | 8 Pages |
Lymphadenopathy occurs in many autoimmune and inflammatory diseases, and vascular proliferation is a common feature in the enlarged lymph nodes. The lymph node vasculature plays critical roles in delivering immune cells as well as oxygen and micronutrients, and therefore represents a potential target for therapeutic manipulation of immunity. In this review, we discuss recent insights made in understanding the growth and function of the vascular and associated stromal compartment in immune-stimulated lymph nodes and the potential utility of altering this process in autoimmune diseases.
► Lymphadenopathy in autoimmune diseases is accompanied by vascular proliferation. ► The regulation and function of lymph node vascular-stromal growth are being studied. ► The lymph node vascular-stromal compartment is a potential therapeutic target.
