Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3257030 | Clinical Immunology | 2012 | 14 Pages |
Abstract
⺠We have demonstrated that vaccination in C2 deficiency gives an antibody response. ⺠The antibody response varies from low to normal in relation to antigen and person. ⺠Specific antibodies induce opsonization with C3 fragments in C2 deficiency. ⺠The antibody-dependent activation of C3 is by a C1q-dependent C2 bypass mechanism. ⺠Our findings suggest that vaccination results in increased bacterial phagocytosis.
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Authors
Göran Jönsson, Christian Lood, Birgitta Gullstrand, Eva Holmström, Barbro Selander, Jean Henrik Braconier, Gunnar Sturfelt, Anders A. Bengtsson, Lennart Truedsson,