| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3257174 | Clinical Immunology | 2012 | 8 Pages |
T-cell deficiency after allogeneic stem cell transplantation (ASCT) is common and has major impact on clinical outcome. In this retrospective study 210 patients were analyzed with regards to levels of T-cell receptor excision circles (TRECs) during the first 24 months after transplantation. We could for the first time show a significant correlation between the use of bone marrow grafts and higher TREC levels > 6 months post-ASCT (p < 0.001). Treatment with anti-thymocyte globulin was correlated with lower TREC levels ≤ 6 months post-ASCT (p < 0.001). Patients with TREC levels above median at 3 months had a superior overall survival, 80% vs. 56% (p = 0.002), and lower transplantation-related mortality, 7% vs. 21% (p = 0.01). We conclude that graft source and conditioning regimen may have a significant effect on T-cell reconstitution after ASCT and can thus affect outcome. These results strongly support the use of TREC measurement as part of the standard repertoire of immunological monitoring after ASCT.
► We evaluated recovery of thymic function in 210 cases after allogeneic stem cell transplantation. ► We measured levels of T-cell receptor excision circles (TRECs) at 6 time-points. ► Bone marrow as graft source was correlated to earlier recovery of TREC levels. ► T-cell depletion with ATG had a negative effect on TREC levels during the first 6 months after SCT. ► TREC levels above median at 3 months post SCT were correlated with improved survival.
