Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3270441 | International Journal of Diabetes Mellitus | 2010 | 6 Pages |
Abstract
The present article is related to the development of psyllium based oral insulin delivery systems that could release insulin in a controlled and sustained manner. Psyllium is a medicinally important gel, forming glucose lowering dietary fiber and drug delivery system developed by its functionalization will have the double potential of curing diabetes. Psyllium and acrylamide/methacrylamide based hydrogels were prepared, and the effect of pH on the release dynamics of insulin from drug loaded hydrogels has been studied to evaluate the drug release mechanism. Non-Fickian diffusion mechanism has been observed for the release of insulin in the pH 7.4 buffer.
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Authors
Baljit Singh, Nirmala Chauhan,