| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3272225 | Journal de Gynécologie Obstétrique et Biologie de la Reproduction | 2015 | 7 Pages |
Abstract
Nifedipine and nicardipine are both calcium channel inhibitors, used off-label as tocolytics in preterm labour. Their use is related to their relaxing effects on uterin muscle by L-type voltage dependent calcium channels blockade. This article describes pharmacological effects, pharmacokinetics properties and tolerance of these drugs. It also discusses serious adverse effects, such as pulmonary edema, reported with both nifedipine and nicardipine in preterm labour.
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Authors
T. Bejan-Angoulvant, J. Crochet, A.-P. Jonville-Bera,