Article ID Journal Published Year Pages File Type
3274760 Médecine des Maladies Métaboliques 2011 12 Pages PDF
Abstract
Type 2 diabetes (T2D) and obesity are multifactorial disorders with a strong genetic basis. The sequencing of the human genome and the Hapmap project of frequent DNA variation have made possible dramatic progress in the understanding of the molecular determinants of both afflictions. Indeed, Genome Wide Association studies (GWAS) have identified dozens of loci contributing to the risk of these conditions. Next Generation Sequencing (NGS) will certainly identify rare functional genetic variants causing extreme diabetes and obesity phenotypes and/or strongly increasing disease risk opening new avenues in metabolic personalized medicine.
Related Topics
Health Sciences Medicine and Dentistry Endocrinology, Diabetes and Metabolism
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