| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3275168 | Médecine des Maladies Métaboliques | 2009 | 5 Pages |
Abstract
The complexity of metabolic disorders involved in type 2 diabetes cannot be currently addressed by the use of a single drug. Nutraceuticals such as resveratrol may be a useful addition to antidiabetic therapy. Resveratrol acts through an array of mechanisms. These involve antioxydative and antiinflammatory effects (NFκB and AP-1 inhibition), mitochondrial activation via PGC-1 and the sirtuin pathway, PPARγ activation and antagonization of diabetogenic pollutants (dioxins, tobacco smoke arylhydrocarbons) through Ah receptor inhibition. Resveratrol thus appears a good candidate as a neutraceutical support for the therapy of obesity and type 2 diabetes.
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Authors
E. Sérée, R. Burcelin, J.-F. Savouret,