Mesure non invasive des produits avancés de glycation par autofluorescence cutanée chez le sujet diabétique

The accumulation of advanced glycation end products (AGEs) in tissues underlies the process called “tissue memory” suggested in prospective studies of diabetic complications i.e. UKPDS and DCCT/EDIC. Levels of AGEs are correlated with degenerative diabetic complications independently of HbA1c levels. The development of non invasive techniques to measure skin AGEs by autofluorescence provides new opportunities to demonstrate the relationships between glycemic levels and diabetic complications. It is important to provide additional clues to the heterogeneity of metabolic and cardiovascular risks. Some studies also indicate a good correlation with microangiopathy. It remains to be established through prospective studies the positive and negative predictive values of this measurement in order to include skin AGE in our routine practice.