Mécanisme d'action hépatique de la metformine dans le diabète de type 2

Metformin is the most frequently oral antidiabetic used to reduce hyperglycemia in type 2 diabetes. Metformin mainly acts on liver to reduce de novo glucose synthesis (gluconeogenesis). Metformin is also able to ameliorate hepatic steatosis by inhibiting lipid synthesis and increasing fatty acid oxidation. Recent observations suggest that metformin would exert its beneficial effects on metabolism through the reduction of intracellular energy charge and activation of AMP-activated protein kinase (AMPK), a key regulator of energy metabolism.