| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3281270 | Clinical Gastroenterology and Hepatology | 2016 | 41 Pages |
Abstract
A score based on MS (glutamate, isoleucine, glycine, lysophosphatidylcholine 16:0, phosphoethanolamine 40:6) and knowledge of AST, fasting insulin, and PNPLA3 genotype is significantly better than a score based on clinical or metabolic profiles alone in determining the risk of NASH.
Keywords
UPLCNAFLDTOFMSNAFLPNPLA3AUROCLysoPCLEULIPHDLhigh-density lipoproteinASTAspartate aminotransferasenonalcoholic steatohepatitisisoleucineIleSERNonalcoholic fatty liver diseasetriacylglycerolTriglyceridesDiagnosisTyrTyrosinevalSerineMetabolic syndromeMass spectrometryTime-of-flight mass spectrometryconfidence intervalphosphatidylethanolamineLeucineLysophosphatidylcholinesLipidomicsMetabolomicMETSarea under the receiver operating characteristic curveInsulin resistanceMETNash Valinepatatin-like phospholipase domain-containing protein 3PredictionLiverNonalcoholic fatty liverUltra-performance liquid chromatographyGas chromatographyGluglutamateGlyGlycine
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Authors
You Zhou, Matej OreÅ¡iÄ, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia Hyötyläinen, Hannele Yki-Järvinen,