Development and Validation of the Framingham Steatosis Index to Identify Persons With Hepatic Steatosis

Article ID	Journal	Published Year	Pages	File Type
3281404	Clinical Gastroenterology and Hepatology	2016	26 Pages	PDF

Abstract

In an analysis of the Framingham Third Generation Cohort, we found the ratio of ALT:AST to identify people with hepatic steatosis more accurately than either ALT or AST alone. We used data from this cohort to develop and validate the FSI, which identifies patients with steatosis with a c-statistic value of about 0.8.

Keywords

FLI Integrated discrimination index FHS NHANES ALT FSI HSI Hepatic steatosis index HDL NAFLD ROC LPR FLD NRI IDI high-density lipoprotein AST Aspartate aminotransferase Alanine aminotransferase National Health and Nutrition Examination Survey Fatty liver disease Nonalcoholic fatty liver disease Diagnostic computed tomography body mass index BMI net reclassification index fatty liver index confidence interval Low-density lipoprotein LDL Framingham Heart Study diagnostic score receiver operator characteristic Liver fat Ion