| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3281542 | Clinical Gastroenterology and Hepatology | 2016 | 30 Pages |
Abstract
In an analysis of data from patients with chronic HCV infection participating in a clinical trial of ledipasvir and sofosbuvir, SVR12 was associated with reduced fatigue, compared with baseline. High baseline serum levels of interferon-γ were associated with fatigue. Reductions in levels of chemokine (C-C motif) ligand 2 were associated with persistent fatigue after SVR12. Central and peripheral fatigue each associated with different biomarkers, suggesting different pathogenic pathways.
Keywords
FSSFACIT-FIL10SF-36SVR12PDGFCH-CALTTNFCLDQMCP-1/CCl2Alanine aminotransferaseinterferonIFNinterleukinFatiguePeripheral fatigueCentral fatiguegranulocyte colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorG-CSFtumor necrosis factorShort Form 36Fatigue severity scalepatient-reported outcomePROchronic hepatitis CHepatitis C virusHCVChronic Liver Disease Questionnaire
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Authors
Lynn Gerber, Michael Estep, Maria Stepanova, Carey Escheik, Ali Weinstein, Zobair M. Younossi,