Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3281638 | Clinical Gastroenterology and Hepatology | 2014 | 7 Pages |
Abstract
Filaggrin, ZO-3, and claudin-1 (but not ZO-1 or ZO-2) are detected in the esophageal mucosa of patients with EoE treated with steroids and individuals without esophageal disease. Without treatment, spongiosis increases, corresponding with reduced levels of filaggrin, ZO-3, and claudin-1. Loss of tight junction regulators and dilation of intercellular spaces appear to be involved in the pathophysiology of EoE and could be targets for treatment.
Keywords
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Authors
David A. Katzka, Ravikanth Tadi, Thomas C. Smyrk, Eesha Katarya, Anamay Sharma, Deborah M. Geno, Michael Camilleri, Prasad G. Iyer, Jeffrey A. Alexander, Navtej S. Buttar,