Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3282096 | Clinical Gastroenterology and Hepatology | 2015 | 39 Pages |
Abstract
In a large, real-life study, 52% of patients with CD who discontinued infliximab upon achieving clinical remission remained in SCR after a median period of approximately 10 years; Most patients remained on immunomodulator therapy. Although patients with CD have variable responses to infliximab, a subgroup achieved long-term remission after infliximab discontinuation.
Keywords
Anti-TNF agentASCAVCAM-1VCAMATIIFXIBDIQRantibodies to infliximabimmImmunomodulatorsInfliximabCrohn’s diseaseInflammatory bowel diseaseELISAEnzyme-linked immunosorbent assayTrough concentrationtumor necrosis factor αSerologyAnti–Tumor Necrosis Factorconfidence intervalTNF-αinterquartile rangevascular cell adhesion molecule-1C-reactive proteinCRPprognosisSCR
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Authors
Konstantinos Papamichael, Niels Vande Casteele, Ann Gils, Sophie Tops, Scott Hauenstein, Sharat Singh, Fred Princen, Gert Van Assche, Paul Rutgeerts, Severine Vermeire, Marc Ferrante,