Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3282301 | Clinical Gastroenterology and Hepatology | 2013 | 12 Pages |
Abstract
Pouchitis is the most common complication among patients with ulcerative colitis who have undergone restorative proctocolectomy with ileal pouch-anal anastomosis. Pouchitis is actually a spectrum of diseases that vary in etiology, pathogenesis, phenotype, and clinical course. Although initial acute episodes typically respond to antibiotic therapy, patients can become dependent on antibiotics or develop refractory disease. Many factors contribute to the course of refractory pouchitis, such as the use of nonsteroidal anti-inflammatory drugs, infection with Clostridium difficile, pouch ischemia, or concurrent immune-mediated disorders. Identification of these secondary factors can help direct therapy.
Keywords
CDINSAIDTNFCARD15nucleotide-binding oligomerization domain containing 2NOD2PSCIBDFAPIPAAiPSFAP, Familial Adenomatous PolyposisIleal pouch-anal anastomosisinterleukinCrohn's diseaseInflammatory bowel diseasenonsteroidal anti-inflammatory drugirritable pouch syndromecytomegalovirusCMVClostridium difficile infectiontumor necrosis factorRestorative proctocolectomyPouchitisPrimary sclerosing cholangitisUlcerative colitisCarpIleal pouch
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Authors
Bo Shen,