Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B With Ultrasound-Defined Steatosis Based on Data From the Third National Health and Nutrition Examination Survey

Article ID	Journal	Published Year	Pages	File Type
3282744	Clinical Gastroenterology and Hepatology	2013	10 Pages	PDF

Abstract

We used data from the National Health and Nutrition Examination Survey III to validate the association between rs738409 (PNPLA3), rs780094 (GCKR), and rs4240624 (PPP1R3B) with HS, with or without increased levels of ALT, among 3 different ancestries. Some, but not all, associations between variants in NCAN, lysophospholipase-like 1, GCKR, and PPP1R3B with HS (with and without increased ALT level) were significant within subpopulations.

Keywords

LYPLAL1 PNPLA3 NHW NHANES III GCKR HDL-C NHB NAFLD EAF ALT AST Aspartate aminotransferase Alanine aminotransferase Mexican American Hepatic steatosis nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Non-Hispanic white Third National Health and Nutrition Examination Survey Non-Hispanic black high-density lipoprotein cholesterol Genome-wide association study Candidate gene study odds ratios Neurocan Nash Replication Glucokinase regulatory protein patatin-like phospholipase domain-containing protein 3 Single-nucleotide polymorphisms SNP

Related Topics

Health Sciences Medicine and Dentistry Gastroenterology

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Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B With Ultrasound-Defined Steatosis Based on Data From the Third National Health and Nutrition Examination Survey

Authors

Ruben Hernaez, Jody McLean, Mariana Lazo, Frederick L. Brancati, Joel N. Hirschhorn, Ingrid B. Borecki, Tamara B. Harris, Genetics of Obesity-Related Liver Disease (GOLD) Consortium Genetics of Obesity-Related Liver Disease (GOLD) Consortium,