Comparison of Total Cortisol, Free Cortisol, and Surrogate Markers of Free Cortisol in Diagnosis of Adrenal Insufficiency in Patients With Stable Cirrhosis

Article ID	Journal	Published Year	Pages	File Type
3282791	Clinical Gastroenterology and Hepatology	2014	34 Pages	PDF

Abstract

Adrenal insufficiency, defined by LDSST, is frequent in patients with stable cirrhosis, on the basis of measurements of total and free cortisol. FCI scores are better than measurement of total cortisol in assessing adrenal function in patients with cirrhosis. We did not associate adrenal dysfunction with outcome, but further studies are needed.

Keywords

CBG ACTH SST ROC FCI CFC Diagnostic assay Liver disease Test Diagnosis coefficient of variability Adrenal function Model for End-Stage Liver Disease HPA Adrenal insufficiency adrenocorticotropic hormone hypothalamus-pituitary-adrenal MELD Corticosteroid-binding globulin receiver operating characteristic

Related Topics

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Comparison of Total Cortisol, Free Cortisol, and Surrogate Markers of Free Cortisol in Diagnosis of Adrenal Insufficiency in Patients With Stable Cirrhosis

Authors

Giuseppe Fede, Luisa Spadaro, Tania Tomaselli, Graziella Privitera, Roberto Scicali, Panayota Vasianopoulou, Evangelos Thalassinos, Nicholas Martin, Michael Thomas, Francesco Purrello, Andrew Kenneth Burroughs,