Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3283906 | Clinical Gastroenterology and Hepatology | 2009 | 6 Pages |
Abstract
Patients with BAM have reduced serum FGF19 which may be useful in diagnosis. We propose a mechanism whereby impaired FGF19 feedback inhibition causes excessive bile acid synthesis that exceeds the normal capacity for ileal reabsorption, producing bile acid diarrhea.
Keywords
FGF19IBABPCYP7A1FGFR4FGF15FXR7α-hydroxy-4-cholesten-3-onefarnesoid X receptorAsbthomeostasis model assessment of insulin resistanceBile acidOstapical sodium-dependent bile acid transporterBAMELISAEnzyme-linked immunosorbent assayorganic solute transporterfibroblast growth factor 15fibroblast growth factor 19Bile acid malabsorptionileal bile acid binding proteinhigh performance liquid chromatographyHPLC
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Authors
Julian R.F. Walters, Ali M. Tasleem, Omer S. Omer, W. Gordon Brydon, Tracy Dew, Carel W. le Roux,