| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3283976 | Clinical Gastroenterology and Hepatology | 2011 | 6 Pages |
Abstract
In a population-based sample of young-onset CRC cases, germline mutations in MLH1, MSH, and/or MSH6 were more prevalent than reported for CRC patients overall. Because only about 5% of young-onset CRC cases had confirmed deleterious or suspected deleterious mutations, further comparative effectiveness research is needed to determine the most appropriate screening strategy for Lynch Syndrome in this high-risk group.
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Authors
Paul J. Limburg, William S. Harmsen, Helen H. Chen, Steven Gallinger, Robert W. Haile, John A. Baron, Graham Casey, Michael O. Woods, Stephen N. Thibodeau, Noralane M. Lindor,