| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3284352 | Clinical Gastroenterology and Hepatology | 2009 | 7 Pages |
Abstract
In one of the largest single-center studies of children with PSC, we found that most children with PSC had inflammatory bowel disease or autoimmune overlap and advanced fibrosis at diagnosis. Levels of alanine aminotransferase and γ-glutamyl transferase were highest in patients with overlap syndrome and lowest in those with small-duct PSC. Levels of serum liver enzymes normalized after therapy with UDCA, including patients with positive autoimmune markers without histologic features of autoimmune hepatitis.
Keywords
MRCPAIHPSCIBDALTUDCAGGTPANCAmagnetic resonance cholangiographyEndoscopic retrograde cholangiopancreatographyASTAspartate aminotransferaseAlanine aminotransferaseALPAlkaline phosphataseperinuclear antineutrophil cytoplasmic antibodyUrsodeoxycholic acidimmunoglobulin Crohn's diseaseInflammatory bowel diseaseAutoimmune hepatitisPrimary sclerosing cholangitisERCP یا endoscopic retrograde cholangiopancreatography Ulcerative colitisgamma glutamyl transferase
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Authors
Tamir Miloh, Ronen Arnon, Benjamin Shneider, Frederick Suchy, Nanda Kerkar,